Degn lab

About The Laboratory for Lymphocyte Biology

The Laboratory for Lymphocyte Biology focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. We investigate these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. Our work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.


March 2023 - Alex and Marjan's paper is getting some attention out there!

March 2023 - Alex and Marjan's paper on B cell activation is finally out in Nature Communications - a groundbreaking new view on the B cell receptor mechanism of activation!

January 2023 - Happy to welcome Yamira and Johannes for bachelor and pre-thesis work in the lab.

New Year 2022 - We're sad to see Thomas leave the lab but super proud that he landed a position with the FACSCore at AU and Steno Diabetes Center AUH - no doubt he'll be an asset! 

December 2022 - Lasse's paper on the role of the extrafollicular response in autoimmune disease is out in Frontiers in Immunology

November 2022 - Happy to welcome Karolina for an Erasmus+ Master's project in the lab.

August 2022 - We're happy to welcome Layla Pohl and Kristian S. Kastberg as new PhD students in the lab.

July 2022 - Excited to see Sofie and Gudrun's paper on maternofetal effects in BXSB mice out in the Journal of Neuroimmunology - and it made the front page!

June 2022 - Congrats to Kristian and Mathias on succesfully defending their Master's theses!

May 2022 - Our new manuscript, explaining how B cells can drive autoimmunity and epitope spreading, is out on SSRN as a pre-print and under review at Cell!

March 2022 - Søren E. Degn is promoted to tenured Associate Professor at the Department of Biomedicine.

March 2022 - Happy to see Lasse's first paper out as a pre-print on bioRxiv - a stunning demonstration of how cutaneous immune stimulation can precipitate global autoimmunity, with the surprising conclusion that this can be driven by extrafollicular responses!

February 2022 - Thrilled to see Alex and Marjan's paper out as a pre-print on ResearchSquare - a novel take on the mechanism of activation of the B cell receptor!

January 2022 - Congrats to Amanda Howarth on completing her Mol. Biol. project.

December 2021 - Super excited to see Kenneth's paper published in Frontiers in Immunology!

September 2021 - Congratulations to Kathrine on starting a PhD in the lab, joint with Steffen Thiel's group!

August 2021 - Congratulations to Sofie on starting a PhD in the lab!

June-September 2021 - Congrats to Kristian and Mathias on succesfully defending their Mol. Med. projects! Congrats to Amanda on completing her Bachelor.

January 2021 - Congrats to Annika, Ella, Emma, Lea, Sonja and Lasse on completing their projects, despite the challenges of COVID-19.

November 2020 - Congratulations to Kenneth on starting a PhD in the lab, joint with Jørgen Kjems's group!

August 2020 - Happy to welcome Annika, Ella, Emma, Lea, Sonja and Lasse to the lab! Also happy to have Kenneth and Sofie back for continuing projects

June 2020 - Congrats to Laura who has defended her Master's thesis and Amanda, Camilla, Mathias and Kenneth who completed their bachelor's projects, despite the challenges associated with the COVID-19 mandated lockdown in the spring

January 2020 - Degnlab welcomes new bachelor students Amanda, Mathias and Kenneth

December, 2019 - Søren E. Degn is awarded a research grant from the Novo Nordisk Foundation

November 2019 - Søren E. Degn is awarded a Sapere Aude Research Leader grant from the Independent Research Fund Denmark

October 2019 - Degnlab Yearly Retreat held at Sandbjerg Estate

September 2019 - New Master's student, Laura, joins the group

August 2019 - The new Department Website has launched and it has a feature article about our work!

July 2019 - New postdoc, Gudrun, joins the group

July 2019 - Congratulations Sofie on completing the bachelor! You will be missed in the group, but we wish you all the best for your Master's programme at the Sino-Danish Center in Beijing!

March 2019 - Congratulations to Cecilia on being awarded a Lundbeckfonden Postdoctoral Fellowship!

March 2019 - We have now moved into the Skou Biomedical Building!

January 2019 - Sofie, bachelor student, joins the lab

November 2018 - Søren E. Degn is supported by the ERC Support Programme of the Independent Research Fund Denmark 

November 2018 - Søren E. Degn is awarded a Carlsberg Foundation Distinguished Investigator Fellowship

September 2018 - Degnlab welcomes Ewa, new postdoc

March 2018 - Cecilia, new postdoc, joins the group

December, 2017 - Søren E. Degn is awarded a research grant from the Novo Nordisk Foundation

November, 2017 - Søren E. Degn is awarded a Lundbeckfonden Fellowship

Department of Biomedicine

Farewell celebration for Thomas - 2022

Degnlab Spring Meeting 2022

Degnlab Yearly Retreat 2020

Degnlab Yearly Retreat 2019

Degnlab Spring 2019