Degn lab

About The Laboratory for Lymphocyte Biology

The Laboratory for Lymphocyte Biology focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. We investigate these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. Our work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.

News

August 2020 - Happy to welcome Annika, Ella, Emma, Lea, Sonja and Lasse to the lab! Also happy to have Kenneth and Sofie back for continuing projects

June 2020 - Congrats to Laura who has defended her Master's thesis and Amanda, Camilla, Mathias and Kenneth who completed their bachelor's projects, despite the challenges associated with the COVID-19 mandated lockdown in the spring

January 2020 - Degnlab welcomes new bachelor students Amanda, Mathias and Kenneth

December, 2019 - Søren E. Degn is awarded a research grant from the Novo Nordisk Foundation

November 2019 - Søren E. Degn is awarded a Sapere Aude Research Leader grant from the Independent Research Fund Denmark

October 2019 - Degnlab Yearly Retreat held at Sandbjerg Estate

September 2019 - New Master's student, Laura, joins the group

August 2019 - The new Department Website has launched and it has a feature article about our work!

July 2019 - New postdoc, Gudrun, joins the group

July 2019 - Congratulations Sofie on completing the bachelor! You will be missed in the group, but we wish you all the best for your Master's programme at the Sino-Danish Center in Beijing!

March 2019 - Congratulations to Cecilia on being awarded a Lundbeckfonden Postdoctoral Fellowship!

March 2019 - We have now moved into the Skou Biomedical Building!

January 2019 - Sofie, bachelor student, joins the lab

November 2018 - Søren E. Degn is supported by the ERC Support Programme of the Independent Research Fund Denmark 

November 2018 - Søren E. Degn is awarded a Carlsberg Foundation Distinguished Investigator Fellowship

September 2018 - Degnlab welcomes Ewa, new postdoc

March 2018 - Cecilia, new postdoc, joins the group

December, 2017 - Søren E. Degn is awarded a research grant from the Novo Nordisk Foundation

November, 2017 - Søren E. Degn is awarded a Lundbeckfonden Fellowship

Department of Biomedicine

Degnlab Spring 2019

Degnlab Yearly Retreat 2019

Degnlab Yearly Retreat 2020

Images

“DEGN LAB” photoactivated inside the white pulp of the spleen. The marginal zone is delineated by in vivo labeling for CD169 (two-photon micrograph).
Cross-sectional confocal micrograph of a follicle in the popliteal lymph node. B cells in green, follicular dendritic cells (FDCs) in red, nuclei in blue.
Conduits of a murine lymph node visualized by FITC painting. Two-photon micrograph.
Follicular dendritic cell network. FDCs in red, macrophages and DCs in green.
Cross-sectional confocal micrograph of follicles in the popliteal lymph node. Macrophages and dendritic cells (DCs) in green, FDCs in red, B cells in blue.
Two-photon micrograph of a Peyer’s patch from an Aicda-Confetti reporter mouse, showing clusters of XFP-labeled B cells (‘Brainbow’ colors). Structural elements containing collagen are visible in blue (second harmonics).