Ferapontov, A., Omer, M., Baudrexel, I.
, Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S.
, Thiel, S., Vorup-Jensen, T., Jungmann, R.
, Kjems, J. & Degn, S. E. (2023).
Antigen footprint governs activation of the B cell receptor.
Nature Communications,
14(1), Article 976.
https://doi.org/10.1038/s41467-023-36672-0
Fahlquist-Hagert, C., Wittenborn, T. R., Terczyńska-Dyla, E., Kastberg, K. S., Yang, E., Rallistan, A. N., Markett, Q. R.
, Winther, G., Fonager, S., Voss, L. F., Pedersen, M. K.
, van Campen, N., Ferapontov, A., Jensen, L., Huang, J., Nieland, J. D., van der Poel, C. E.
, Palmfeldt, J., Carroll, M. C.
... Degn, S. E. (2023).
Antigen presentation by B cells enables epitope spreading across an MHC barrier.
Nature Communications,
14(1), Article 6941.
https://doi.org/10.1038/s41467-023-42541-7
Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023).
Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types.
Cancers,
15(6), Article 1830.
https://doi.org/10.3390/cancers15061830
Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F.
, Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E.
, Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023).
STING activation counters glioblastoma by vascular alteration and immune surveillance.
Cancer Letters,
579, Article 216480.
https://doi.org/10.1016/j.canlet.2023.216480
Sirinian, C., Papanastasiou, A. D., Karayel, O.
, Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022).
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness.
NeoPlasia,
33, Article 100836.
https://doi.org/10.1016/j.neo.2022.100836
Brandt, C. B., Fonager, S. V., Haskó, J., Helmig, R. B., Degn, S., Bolund, L., Jessen, N., Lin, L. & Luo, Y. (2022).
HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes.
Biomolecules,
13(1), Article 23.
https://doi.org/10.3390/biom13010023
Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022).
Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring.
Journal of Neuroimmunology,
370, Article 577927.
https://doi.org/10.1016/j.jneuroim.2022.577927
Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K.
, Jensen, L., Papanastasiou, A. D.
, Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022).
The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.
Frontiers in Immunology,
13, Article 1021370.
https://doi.org/10.3389/fimmu.2022.1021370
Green, K., Wittenborn, T. R., Fahlquist-Hagert, C., Terczynska-Dyla, E., van Campen, N., Jensen, L., Reinert, L., Hartmann, R., Paludan, S. R. & Degn, S. E. (2021).
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.
Frontiers in Immunology,
12, Article 782558.
https://doi.org/10.3389/fimmu.2021.782558
Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H.
, Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P.
, Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021).
Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
Proceedings of the National Academy of Sciences,
118(30), Article e2106647118.
https://doi.org/10.1073/pnas.2106647118
Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021).
Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras.
PLOS ONE,
16(3), Article e0247501.
https://doi.org/10.1371/journal.pone.0247501
Sirinian, C., Papanastasiou, A. D.
, Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021).
Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis).
Genes,
12(11), Article 1686.
https://doi.org/10.3390/genes12111686
van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D.
, Degn, S. E. & Carroll, M. C. (2019).
Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB.
Cell Reports,
29(9), 2745-2755.e4.
https://doi.org/10.1016/j.celrep.2019.10.086
Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I.
, Degn, S. E., Georgiou, P. & Mouzaki, A. (2018).
Clinical and immunological parameters of Sjögren's syndrome.
Autoimmunity Reviews,
17(10), 1053-1064.
https://doi.org/10.1016/j.autrev.2018.05.005
Degn, S. E., van der Poel, C. E., Firl, D. J., Ayoglu, B., Al Qureshah, F. A., Bajic, G., Mesin, L., Reynaud, C.-A., Weill, J.-C., Utz, P. J., Victora, G. D. & Carroll, M. C. (2017).
Clonal Evolution of Autoreactive Germinal Centers.
Cell,
170(5), 913-926.
https://doi.org/10.1016/j.cell.2017.07.026
Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017).
Endogenous Natural Complement Inhibitor Regulates Cardiac Development.
Journal of Immunology,
198(8), 3118-3126.
https://doi.org/10.4049/jimmunol.1601958
Bajic, G., Degn, S. E., Thiel, S. & Andersen, G. R. (2015).
Complement activation, regulation, and molecular basis for complement-related diseases.
E M B O Journal,
34(22), 2735-2757.
https://doi.org/10.15252/embj.201591881
Degn, S. E., Kjaer, T. R., Kidmose, R. T., Jensen, L., Hansen, A. G., Tekin, M.
, Jensenius, J. C., Andersen, G. R. & Thiel, S. (2014).
Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes.
Proceedings of the National Academy of Sciences,
111(37), 13445-13450.
https://doi.org/10.1073/pnas.1406849111
Degn, S. E., Jensen, L., Olszowski, T.
, Jensenius, J. C. & Thiel, S. (2013).
Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44.
Journal of Immunology,
191(3), 1334-45.
https://doi.org/10.4049/jimmunol.1300780
Chatterjee, P., Agyemang, A. F., Alimzhanov, M. B.
, Degn, S. E., Tsiftsoglou, S. A., Alicot, E., Jones, S. A., Ma, M. & Carroll, M. C. (2013).
Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.
European Journal of Immunology,
43(9), 2441-50.
https://doi.org/10.1002/eji.201343412
Brinkmann, C. R., Jensen, L., Dagnaes-Hansen, F., Holm, I. E., Endo, Y., Fujita, T.
, Thiel, S., Jensenius, J. C. & Degn, S. E. (2013).
Mitochondria and the lectin pathway of complement.
Journal of Biological Chemistry.
https://doi.org/10.1074/jbc.M112.430249
Degn, S. E., Jensen, L., Hansen, A. G., Duman, D., Tekin, M.
, Jensenius, J. C. & Thiel, S. (2012).
Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function.
Journal of Immunology,
189(8), 3957-69.
https://doi.org/10.4049/jimmunol.1201736
Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J.
& Jensenius, J. C. (2012).
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components.
Clinical and Experimental Immunology. Supplement,
169(1), 38-48.
https://doi.org/10.1111/j.1365-2249.2012.04584.x
Degn, S. E., Andersen, S. H., Jensen, L., Thiel, S. & Jensenius, J. C. (2011).
Assay interference caused by antibodies reacting with rat kappa light-chain in human sera.
Journal of Immunological Methods,
372(1-2), 204-8.
https://doi.org/10.1016/j.jim.2011.06.030
Degn, S. E., Thiel, S., Nielsen, O.
, Hansen, A. G., Steffensen, R. & Jensenius, J. C. (2011).
MAp19, the alternative splice product of the MASP2 gene.
Journal of Immunological Methods,
373(1-2), 89-101.
https://doi.org/10.1016/j.jim.2011.08.006
Gonzalez, S. F.
, Degn, S. E., Pitcher, L. A., Woodruff, M., Heesters, B. A. & Carroll, M. C. (2011).
Trafficking of B cell antigen in lymph nodes.
Annual Review of Immunology,
29, 215-233.
Degn, S. E., Jensen, L., Gál, P., Dobó, J., Holmvad, S. H.
, Jensenius, J. C. & Thiel, S. (2010).
Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system.
Journal of Immunological Methods,
361(1-2), 37-50.
https://doi.org/10.1016/j.jim.2010.07.006
Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A.
, Degn, S. E., Kim, Y.-A., Cloninger, M. J., Martinez-Pomares, L., Gordon, S., Turley, S. J. & Carroll, M. C. (2010).
Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.
Nature Immunology,
11(5), 427-435.
Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A.
, Degn, S. E., Turley, S. J. & Carroll, M. C. (2010).
Complement-dependent transport of antigen into B cell follicles.
Journal of Immunology,
185, 2659-2664.
Degn, S. E., Hansen, A., Steffensen, R., Jacobsen, C., Jensenius, J. C. & Thiel, S. (2009).
MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.
Journal of Immunology,
183(11), 7371-8.
https://doi.org/10.4049/jimmunol.0902388
Thiel, S., Kolev, M.
, Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M.
& Jensenius, J. C. (2009).
Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.
Journal of Immunology,
182(5), 2939-47.
https://doi.org/10.4049/jimmunol.0802053