Publications

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Gonzalez, S. F., Degn, S. E., Pitcher, L. A., Woodruff, M., Heesters, B. A. & Carroll, M. C. (2011). Trafficking of B cell antigen in lymph nodes. Annual Review of Immunology, 29, 215-233.

Degn, S. E. & Tolar, P. (2025). Towards a unifying model for B-cell receptor triggering. Nature Reviews Immunology, 25(2), 77-91. Article 976. https://doi.org/10.1038/s41577-024-01073-x

Degn, S. E., Jensenius, J. C. & Thiel, S. (2014). The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function. Journal of Immunology, 192(12), 5447-8. https://doi.org/10.4049/jimmunol.1400777

Degn, S. E. (2010). The Lectin Pathway Serine Proteases and Associated Proteins. Aarhus Universitet.

Degn, S. E., Jensenius, J. C. & Bjerre, M. (2010). The lectin pathway and its implications in coagulation, infections and auto-immunity. Current Opinion in Organ Transplantation. https://doi.org/10.1097/MOT.0b013e32834253df

Krimpenfort, L. T., Degn, S. E. & Heesters, B. A. (2024). The follicular dendritic cell: At the germinal center of autoimmunity? Cell Reports, 43(3), Article 113869. https://doi.org/10.1016/j.celrep.2024.113869

Voss, L. F., Howarth, A. J., Wittenborn, T. R., Hummelgaard, S., Juul-Madsen, K., Kastberg, K. S., Pedersen, M. K., Jensen, L., Papanastasiou, A. D., Vorup-Jensen, T., Weyer, K. & Degn, S. E. (2022). The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus. Frontiers in Immunology, 13, Article 1021370. https://doi.org/10.3389/fimmu.2022.1021370

Fahlquist-Hagert, C., Wittenborn, T. R., Pedersen, M. K., Jensen, L. & Degn, S. E. (2024). T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity. iScience, 27(10), Article 110887. https://doi.org/10.1016/j.isci.2024.110887

Fahlquist Hagert, C. & Degn, S. E. (2020). T follicular regulatory cells: Guardians of the germinal centre? Scandinavian Journal of Immunology, 92(4), Article e12942. https://doi.org/10.1111/sji.12942

Degn, S. E., van der Poel, C. E. & Carroll, M. C. (2017). Targeting autoreactive germinal centers to curb autoimmunity. OncoTarget, 8(53), 90624-90625. https://doi.org/10.18632/oncotarget.21701

Joseph, J. V., Blaavand, M. S., Cai, H., Vernejoul, F., Knopper, R. W., Lindhardt, T. B., Skipper, K. A., Axelgaard, E., Reinert, L., Mikkelsen, J. G., Borghammer, P., Degn, S. E., Perouzel, E., Hager, H., Hansen, B., Kalucka, J. M., Vendelbo, M., Paludan, S. R. & Thomsen, M. K. (2023). STING activation counters glioblastoma by vascular alteration and immune surveillance. Cancer Letters, 579, Article 216480. https://doi.org/10.1016/j.canlet.2023.216480

Pohl, L., Wittenborn, T. R., Shahrokhtash, A., Kastberg, K. S., Fahlquist-Hagert, C., Jensen, L., Pedersen, S. A., Demtröder, J. K., Sardella, D., Pulfer, A., Sutherland, D., Gonzalez, S. F., Schiessl, I. M. & Degn, S. E. (2026). Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen. iScience, 29(4), Article 115340. https://doi.org/10.1016/j.isci.2026.115340

Hagert, C. F., Bohn, A. B., Wittenborn, T. R. & Degn, S. E. (2020). Seeing the Confetti Colors in a New Light Utilizing Flow Cytometry and Imaging Flow Cytometry. Cytometry. Part A, 97(8), 811-823. https://doi.org/10.1002/cyto.a.24032

Degn, S. E., Jensenius, J. C. & Thiel, S. (2013). Response to comment on "Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function". Journal of Immunology, 190(6), 2477-8. https://doi.org/10.4049/jimmunol.1390003

Degn, S. E., Thiel, S. & Jensenius, J. C. (2013). Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor. Protein Expression and Purification, 88(2), 173-182. https://doi.org/10.1016/j.pep.2013.01.002

Sirinian, C., Papanastasiou, A. D., Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021). Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). Genes, 12(11), Article 1686. https://doi.org/10.3390/genes12111686

Thiel, S., Kolev, M., Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M. & Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Journal of Immunology, 182(5), 2939-47. https://doi.org/10.4049/jimmunol.0802053

Andersen, S., Assing, K., Jensen, J., Rasmussen, L. D., Laursen, C. B., Dellgren, C. D., Hinke, D. M., Degn, S. E. & Mogensen, T. H. (2026). Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome. Journal of human immunity, 2(3), Article e20250119. https://doi.org/10.70962/jhi.20250119

Degn, S. E., Thiel, S. & Jensenius, J. C. (2007). New perspectives on mannan-binding lectin-mediated complement activation. Immunobiology, 212, 301-11.

Rovsing, A. B., Green, K., Jensen, L., Nielsen, I. H., Mikkelsen, J. G. & Degn, S. E. (2025). Multiparametric Optimization of Human Primary B-Cell Cultures Using Design of Experiments. Scandinavian Journal of Immunology, 102(2), Article e70043. https://doi.org/10.1111/sji.70043

Brinkmann, C. R., Jensen, L., Dagnaes-Hansen, F., Holm, I. E., Endo, Y., Fujita, T., Thiel, S., Jensenius, J. C. & Degn, S. E. (2013). Mitochondria and the lectin pathway of complement. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M112.430249

Fonager, S. V., Winther, G., Weber, Y. C. L., Wittenborn, T. R., Kastberg, K. S., Terczyńska-Dyla, E., Jensen, L., Hansen, L. A., Carroll, M. C., Luo, Y., Lin, L. & Degn, S. E. (2025). Maternal imprinting of autoreactivity in a murine model of systemic lupus erythematosus. Brain, Behavior, and Immunity, 129, 921-934. https://doi.org/10.1016/j.bbi.2025.07.025

Degn, S. E., Hansen, A., Steffensen, R., Jacobsen, C., Jensenius, J. C. & Thiel, S. (2009). MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. Journal of Immunology, 183(11), 7371-8. https://doi.org/10.4049/jimmunol.0902388

Degn, S. E., Thiel, S., Nielsen, O., Hansen, A. G., Steffensen, R. & Jensenius, J. C. (2011). MAp19, the alternative splice product of the MASP2 gene. Journal of Immunological Methods, 373(1-2), 89-101. https://doi.org/10.1016/j.jim.2011.08.006

Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J. & Jensenius, J. C. (2012). Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clinical and Experimental Immunology, Supplement, 169(1), 38-48. https://doi.org/10.1111/j.1365-2249.2012.04584.x

Degn, S. E., Jensen, L., Hansen, A. G., Duman, D., Tekin, M., Jensenius, J. C. & Thiel, S. (2012). Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function. Journal of Immunology, 189(8), 3957-69. https://doi.org/10.4049/jimmunol.1201736

Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W., Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025). LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling. Pigment Cell & Melanoma Research, 38(5), Article e70053. https://doi.org/10.1111/pcmr.70053

Sirinian, C., Marchianò, F., Kenanidou, E., Zaverdas, H., Samiotaki, M., Ioannou, A. M., Theofilatos, K., Argentou, M. I., Degn, S. E., Peroukidis, S., Rusan, M., Zolota, V., Koutras, A., Mavroudi, S., Kourea, H., Ng, C. K. Y. & Papanastasiou, A. D. (2026). Intratumoral collagen correlates with histological grade and patient prognosis in breast cancer. Experimental and Molecular Pathology, 147, Article 105066. https://doi.org/10.1016/j.yexmp.2026.105066

Wittenborn, T. R., Hagert, C. & Degn, S. E. (2019). Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity. Journal of visualized experiments : JoVE, 2019(146), Article e59397. https://doi.org/10.3791/59397

Fonager, S. V., Winther, G., Wittenborn, T. R., Jensen, L., Fahlquist-Hagert, C., Hansen, L. A., Füchtbauer, E.-M., Romero-Ramos, M. & Degn, S. E. (2022). Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring. Journal of Neuroimmunology, 370, Article 577927. https://doi.org/10.1016/j.jneuroim.2022.577927

Degn, S. E. & Thiel, S. (2013). Humoral pattern recognition and the complement system. Scandinavian Journal of Immunology, 78(2), 181-93. https://doi.org/10.1111/sji.12070

Brandt, C. B., Fonager, S. V., Haskó, J., Helmig, R. B., Degn, S., Bolund, L., Jessen, N., Lin, L. & Luo, Y. (2023). HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes. Biomolecules, 13(1), Article 23. https://doi.org/10.3390/biom13010023

Fahlquist-Hagert, C., Wittenborn, T. R., Ferapontov, A., Jensen, L., Terczyńska-Dyla, E. & Degn, S. E. (2024). Haplosufficiency of MHCII in autoreactive germinal center B cells. European Journal of Immunology, 54(1), Article 2350422. https://doi.org/10.1002/eji.202350422

van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D., Degn, S. E. & Carroll, M. C. (2019). Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. Cell Reports, 29(9), 2745-2755.e4. https://doi.org/10.1016/j.celrep.2019.10.086

Pilati, D., Agyei, E. K., Elkhashab, M., Fuchs, E., Nielsen, I. H., Bjerg, T. W., Anthi, A. K., Jiménez-Reinoso, A., Iversen, M. B., Pohl, L., Narita, R., Frago, S., Jakobsen, M. R., Andersen, J. T., Degn, S. E., Paludan, S. R., Alvarez-Vallina, L. & Howard, K. A. (2025). Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction. Journal of Biological Chemistry, 301(6), Article 108508. https://doi.org/10.1016/j.jbc.2025.108508

Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023). Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types. Cancers, 15(6), Article 1830. https://doi.org/10.3390/cancers15061830

Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017). Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Journal of Immunology, 198(8), 3118-3126. https://doi.org/10.4049/jimmunol.1601958

Sirinian, C., de Lastic, A. L., Zaverdas, H., Nifora, M., Georgakopoulou, D., Samiotaki, M., Argentou, M. I., Peroukidis, S., Degn, S. E., Rusan, M., Theofilatos, K., Mavroudi, S., Papanastasiou, A. D. & Koutras, A. (2026). Dual Role of Cancer Epithelial-Specific TRAF3 in Regulating Breast Cancer Cell Survival and Lymphocyte Activity. International Journal of Molecular Sciences , 27(10), Article 4414. https://doi.org/10.3390/ijms27104414

Degn, S. E., Jensenius, J. C. & Thiel, S. (2011). Disease-causing mutations in genes of the complement system. American Journal of Human Genetics, 88(6), 689-705. https://doi.org/10.1016/j.ajhg.2011.05.011

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Wang, F., Ren, J., Zhou, Y., Huo, W., Liu, H., Qin, M., Jing, Y., Yin, Z., Shi, T., Shan, H., Tan, G., Wang, H., Guo, X., Mei, J., Yue, Z., Hou, Z., Zhou, H., Song, J., Degn, S. E. ... Jiang, Y. (2026). Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system. Nature Communications, 17(1), Article 6031. https://doi.org/10.1038/s41467-026-72642-y

Gonzalez, S. F., Lukacs-Kornek, V., Kuligowski, M. P., Pitcher, L. A., Degn, S. E., Turley, S. J. & Carroll, M. C. (2010). Complement-dependent transport of antigen into B cell follicles. Journal of Immunology, 185, 2659-2664.

Chatterjee, P., Agyemang, A. F., Alimzhanov, M. B., Degn, S. E., Tsiftsoglou, S. A., Alicot, E., Jones, S. A., Ma, M. & Carroll, M. C. (2013). Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner. European Journal of Immunology, 43(9), 2441-50. https://doi.org/10.1002/eji.201343412

Bajic, G., Degn, S. E., Thiel, S. & Andersen, G. R. (2015). Complement activation, regulation, and molecular basis for complement-related diseases. EMBO Journal, 34(22), 2735-2757. https://doi.org/10.15252/embj.201591881

Degn, S. E., Kjaer, T. R., Kidmose, R. T., Jensen, L., Hansen, A. G., Tekin, M., Jensenius, J. C., Andersen, G. R. & Thiel, S. (2014). Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. Proceedings of the National Academy of Sciences (PNAS), 111(37), 13445-13450. https://doi.org/10.1073/pnas.1406849111

Wittenborn, T. R., Hagert, C. F., Ferapontov, A., Fonager, S., Jensen, L., Winther, G. & Degn, S. E. (2021). Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. PLoS One, 16(3), Article e0247501. https://doi.org/10.1371/journal.pone.0247501

Degn, S. E., Jensen, L., Olszowski, T., Jensenius, J. C. & Thiel, S. (2013). Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. Journal of Immunology, 191(3), 1334-45. https://doi.org/10.4049/jimmunol.1300780

Degn, S. E., van der Poel, C. E., Firl, D. J., Ayoglu, B., Al Qureshah, F. A., Bajic, G., Mesin, L., Reynaud, C.-A., Weill, J.-C., Utz, P. J., Victora, G. D. & Carroll, M. C. (2017). Clonal Evolution of Autoreactive Germinal Centers. Cell, 170(5), 913-926.e19. https://doi.org/10.1016/j.cell.2017.07.026

Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I., Degn, S. E., Georgiou, P. & Mouzaki, A. (2018). Clinical and immunological parameters of Sjögren's syndrome. Autoimmunity Reviews, 17(10), 1053-1064. https://doi.org/10.1016/j.autrev.2018.05.005

Juul-Madsen, K., Troldborg, A., Wittenborn, T. R., Axelsen, M. G., Zhao, H., Klausen, L. H., Luecke, S., Paludan, S. R., Stengaard-Pedersen, K., Dong, M., Møller, H. J., Thiel, S., Jensen, H., Schuck, P., Sutherland, D. S., Degn, S. E. & Vorup-Jensen, T. (2021). Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus. Proceedings of the National Academy of Sciences (PNAS), 118(30), Article e2106647118. https://doi.org/10.1073/pnas.2106647118

Displaying results 1 to 50 out of 63

Revised 11.09.2025